Weight Report

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Dr. Daniel Wallerstorfer

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Dr. Daniel Wallerstorfer

My name is Dr. Daniel Wallerstorfer.

I am a molecular biologist and biotechnologist. Together with my team, I have developed this genetic analysis program.

I myself suffer from a genetic kidney disease. It will lead to me needing a donor kidney at some point. And I'm not alone in this. Today, there are approximately 6,000 diseases that are caused by defects in genes and bring many difficult fates with them.

In addition to these rare, but serious diseases, there are also many common genetic defects. Although they significantly increase the risk of certain diseases, they do not inevitably lead to a negative outcome. However, we do not have to be slaves to our inherent genetics. Therefore, I have made it my mission to take action against genetically determined destinies.

My personal goal

I want to eradicate genetic diseases and improve human health. The focus of this analysis is weight management. Obesity and excessive weight are linked to many diseases and poor health and our genetics play a significant role in how our bodies lose and gain weight. In this rapidly growing field of research, we learn how genes interact with our diet and metabolism. Our goal is to identify the correct macronutrients and strategies that can support you in effectively losing weight or maintaining a healthy weight.

I wish you an exciting journey into the world of your nutrition genes - and more importantly; a successful path to your healthy future.

I'm happy to accompany you on this journey.

Dr. Daniel Wallerstorfer BSc.

Chief Scientific Officer, 10X Health

Learn More About Yourself

Much more.


The connection between genetics and health is profound and offers great potential for preventative and personalized approaches. By deciphering the information in your genes, we can gain valuable insights that can help elevate your health to a new level.

I am pleased to embark on a healthier future together with you.


What are genes?

Genes Structure Diagram

Through the interplay of your approximately 23,000 different genes, the unique complexity of your body is created.

What are genes?

Let's start with your body. It consists of about 50 trillion individual cells, i.e. 50,000,000,000,000 cells. Almost every cell contains a nucleus, which holds your 3.2 billion genetic letters, i.e. your genetic code. (In the form of a text file, a tiny fraction of your genetic code, it would look like this: ATCGATCTTCGCAAATCTTGA.

Now, let's take a closer look at the genes. A single gene is a specific area of our genetic code. It contains the information on how the body must carry out a certain process. Every person usually has two copies of each gene, one from each parent. These two gene copies may be identical or slightly different, leading to variations in the expression of certain traits. This is why we refer to genes in plural in this report, especially in the results.

Every gene controls a specific process. For example, there are genes that tell the body what color it should produce in the eyes. There are also genes that make our skin produce natural sun protection, genes that ensure strong bones, and other genes that tell the intestines how to digest lactose in milk.

Through the interplay of your approximately 23,000 different genes, the unique complexity of your body is created.

When genes do not work correctly

And now we come to the problem. Genes are not infallible and each of us has inherited certain spelling mistakes in our genes from our parents.

A gene is a very precise instruction to the body how to carry out a specific process. For this process to work, the cell needs to be able to understand the instruction of the gene. Inherited errors in the genetic instruction of a gene disrupt this process, leading to the body lacking this one important function for health and nutrition.

But do not worry, if you read about gene defects we have identified in your genes. These are all very common and one of the reasons why we are all different with our own strengths and weaknesses. We have carefully chosen to test only for defective genes, where you have the ability to compensate for the lost or reduced function with other means such as your nutrition or lifestyle.

According to estimates, each person has about 2,000 genetic defects which negatively affect their health.

Good to know

What do defective and effective genes mean? The term is conceptually correct, but scientifically unusual.
  • The term was chosen to make the complexity of genetics easier to understand. In science, we talk about gene variations, polymorphisms, deletions and insertions, among other things. The negative effects do not always have to mean a total failure of the genes.
  • In your report, I always refer to favorable gene variations as 'effective' or 'functional' genes and unfavorable gene variations as 'defective' genes.

Disclaimer

The possibilities and limits of science

Science

Effects of genetic defects on your body according to scientific studiesToday, there are already about 4 million scientific publications that examine the effects of certain gene defects on the human body. A typical finding from this sounds something like this: 'If you have gene defect X, vitamin Y cannot be converted and remains ineffective.' Only when the effects of a gene defect have been independently demonstrated by at least three different studies, is the gene test included in the program. Therefore, the influence of a gene defect is always backed by several scientific studies and you can find the sources for this at the end of each chapter.

Recommendation

Recommendations based on your genetic profileThe recommendations derived from your genetic traits are often not determined by studies, but are mostly logical conclusions. For example: If a certain vitamin doesn't work due to a gene variation, the conclusion is to switch to another vitamin with a similar effect. We achieve this by changing your diet or supplementation. Therefore, it is important to understand that the recommendations developed by our experts are not based on randomized, placebo-controlled studies, but were created as logical conclusions based on your genetic traits.

Scientific confirmation and Legal Conclusion diagram

Terminology

What do defective and effective genes mean? The terms are conceptually correct, but scientifically unusual. The terms were chosen to make the complexity of genetics easier to understand. In science, we talk about gene variations, polymorphisms, deletions and insertions, among other things. The negative effects do not always have to mean a total failure of the genes. In your report, I always refer to favorable gene variations as 'effective' or 'functional' genes and unfavorable gene variations as 'defective' genes.

How is your report structured?

In this report, you will find a detailed evaluation of your own genes along with an explanation of what this means for you. I would like to guide you through this report and bring you closer to your results, the science behind it, and the recommendations for you. This will allow you to use the newly acquired knowledge as best as possible.

Only summary - or also backgrounds?

If you only want to know your results, you will find a summary of your genetic strengths and weaknesses in the first part. If you're more curious about the backgrounds of your genes, you will find detailed information and explanations in the respective chapters.

Fundamentally, this report is divided into many small chapters. Each is similarly structured. First, I briefly explain the topic to you. Then, we look at the results of your gene analysis together.

Further information

Many topics in genetics - such as the ability to detoxify pollutants - are not black or white but can lie somewhere in between, especially when multiple genes are responsible for a protective function. In such cases, graphics show where your genetic result lies between the two extremes (good/bad). This allows you to estimate your genetic risk and react accordingly.

Your body is a combination of more than 23,000 different genes that control the various aspects of your body. Therefore, it is important to consider a genetic aspect, not in isolation, but in the context of your entire body and the other genes. In your ‚Precision Nutrition Plan' report there is a section titled ‚Your Nutrient & Lifestyle Requirements', here is where we ask ourselves what exactly your results mean for your body, your diet and your health.

Good to know

  • In many parts of the report, there are links to videos where I can explain the topic to you in more detail.

Your Results at a Glance

Results Overview


Find out, at a glance, the results of your personal genetic analysis. Which genes are working - and where is action needed? On the following pages, you will find detailed explanations for all results.


Gene overview

Please see below a description of each of the genes considered whilst creating your analysis.

ADORA2A
(rs5076714)

A receptor for adrenaline / epinephrine, exerting its effect on the sympathetic nervous system.

ADRB3
(rs4994)

A receptor for adrenaline / epinephrine, exerting its effect on the sympathetic nervous system.

APOA1
(rs5082)

A component of high-density lipoprotein (HDL) that carries high density cholesterol within the blood, regulating cholesterol levels.

APOA5
(rs662799)

An important protein for regulating triglyceride levels by interacting with the LDL receptors genes.

FABP2
(rs1799883)

Involved in the transport and uptake of long chain fatty acids, important components of metabolic health.

FTO
(rs9939609)

Thought to be involved in insulin secretion and pancreatic function.

PPARG
(rs1801282)

An important protein for regulating fatty acid storage and glucose metabolism.

Science Statement

There are approximately 4 million scientific publications on genetics. Only when a gene effect is reported to have the same outcome by at least three independent studies, we include it in your analysis. This science is delivered throughout your report.

Lose weight

Weight loss tailored: How genetic differences influence the success of weight reduction.

This is how you should consume your daily calories:

20%

from fat

60%

from Carbohydrates

20%

from Protein

You are a very good carbohydrate metabolizer

Moderate sensitivity to fat
Excessive intake of fat calories leads to moderate weight gain.
Low sensitivity to carbohydrates
Carbohydrate calories lead to minimal weight gain.
Moderate protein sensitivity
Protein calories in very large quantities lead to moderate weight gain.
Chapter: Your nutritional type

Reduce weight

336

kcal/day

burnt through training

514

kcal/day

saved via food

Losing weight through calorie reduction is not effective
Saving calories by eating less only leads to slight weight reduction.
Losing weight through training is moderately effective
Burning calories through training leads to moderate weight loss.
Calorie reduction
Exercise

Athletic Type: Training is more effective for you in reducing your weight. A calorie reduction by eating less, on the other hand, leads to less success.

Chapter: Exercise or calorie reduction

Perform

30%

Strength training

70%

Endurance training

You are an endurance type

Muscle mass loss low
Due to your genes, you tend to lose less muscle mass than other individuals when you reduce your calorie intake. For this reason, endurance training is sufficient for you to optimally support your muscle mass.
Chapter: Preservation of your muscle mass
Strong hunger type
Your genes burden you with a stronger feeling of hunger than is the case with people with more favorable genes. It's better to distribute your meals over six small ones instead of three big ones per day. This enables you to avoid longer periods without food. The last part of the report lists snacks that are always allowed in between.
Chapter: Control over feelings of hunger an satiation
Moderate calorie intake type
Due to your genes, you may be more tempted to opt for particularly high-calorie foods. Therefore, be aware that your genes may sometimes try to entice you. For this reason, stick to the green-rated foods in your individual food list found in the last part of your report to counteract your genes.
Chapter: Control over feelings of hunger an satiation
Weak satiety type
Due to your genes, the signal from your body that it is actually full slows down. This often leads to uncontrollable overeating. You will find it difficult to maintain longer breaks between meals. Take enough time during your meals to give your body a chance to develop the feeling of fullness.
Chapter: Control over feelings of hunger an satiation
Strong snacking tendency
Due to your genes, you tend to snack more often than people with other genes. Be aware of this temptation and make sure you reach for low-calorie options when you feel the need. A list of recommended snacks can be found in the last part of your report.
Chapter: Control over feelings of hunger an satiation
Weak fatty organ type
Your genes protect you from excessive fat deposits around the organs within your abdomen. Fat around the organs is metabolically active. This means that it is worse for your health than fat around your hips. Therefore, your genes offer you optimal protection here.
Chapter: Fat distribution
Weak yo-yo type
Your genes protect you from rapid weight regain after a successful weight loss program. Your genes help you maintain your weight more easily. However, after successful weight loss, make sure to follow the basic rules of this report to support your body.
Chapter: Hit your desired weight

Tailored Weight Loss

Nutritional Type


How genetic differences influence the success of weight loss.

Find out, according to your genes, whether you are fat metabolizing type, carbohydrate or a mixed metabolized type.


Video thumbnail

How genes influence which calories make you gain weight

You probably know someone who seems to be able to eat whatever they want without gaining a single ounce of fat. Others, however, seem to gain weight just by looking at fast food. Therefore, it's probably no surprise to you that calories affect each of us differently. The careful counting of calories to monitor body weight, has its limits.

To understand how our macronutrient distribution (fats, carbohydrates, and proteins) works, let's take a closer look at the individual components now.

In fact, studies suggest that our body weight is largely influenced by our genes. Scientists estimate that about 60 to 80 percent of overweight issues are due to genetic causes.

Fats simply explained

Fat is the energy supplier with the highest energy density. Here we differentiate between saturated and unsaturated fatty acids.

Generally bad: Saturated fatty acidsSaturated fatty acids are considered rather unhealthy. They are usually found in animal foods such as butter, tallow, lard, meat, and milk. Vegetable fats like coconut fat, palm oil, and cocoa butter also contain saturated fatty acids. The body mainly uses saturated fatty acids as an energy supplier and storage. So, if you want to eat healthily and have the desire to lose weight, these fatty acids are your enemy. Saturated fatty acids should make up a maximum of one third of your daily fat intake.

These are the good ones: unsaturated fatty acidsAs a counterpart, there are the unsaturated fatty acids, which are referred to as the 'healthy fats'. Unsaturated fatty acids are primarily found in vegetable oils and fish. Certain unsaturated fatty acids are essential for us and have many important functions in the body. At least two-thirds of the daily fat calories should come from these healthy fats.

How your genes influence fat absorption

Diagram showing how genes influence fat absorption: 720 people consume more fat, with some maintaining normal weight and others experiencing weight gain based on genetic differences

In a study, people were given a large amount of extra fat calories to see how body weight would respond. The result: Some people gained weight as expected, while others surprisingly managed to maintain their weight despite the excess of fat calories. The causes were differences in the effectiveness of the FABP2-genes.

Important to know

  • The recommendation on how much fat one should really consume depends on one's genes. In addition to the FABP2-genes, several other genes also play a role in your fat intake.

Fats and the process in the body

If the genes are effective

In people with effective genes, the excessive fat intake is blocked.

1

Nutritional fats are consumed in the form of food.

2

Once the required amount of fat has been absorbed from the intestine, the effective genes block further fat absorption.

3

The excess fat is not absorbed and is then excreted.

Gene diagram from page 26

If the genes are defective

In people with defective genes, the excess fat is absorbed into the body.

1

Nutritional fats are ingested in the form of food.

2

The defective genes cannot block excessive fat intake.

3

The excess fat is absorbed into the body.

Gene diagram from page 27

Daniel, here is your result

Moderate sensitivity to fat
Due to your genes, you tend to absorb and store more fat from the intestines than people with other genes. Therefore, high fat content in food may lead to becoming overweight more easily. The main concern is total fat. Therefore, it would be preferable to consume healthy, unsaturated fat.
Gene Genotype Function
FABP2 (rs1799883) C/C
PPARG (rs1801282) C/C
FTO (rs9939609) T/A
APOA2 (rs5082) A/A
APOA5 (rs662799) A/A

Your genes are impaired

Since your genes are impaired, a bit too much fat is absorbed from the diet.

1

The amount of fat you consume must be reduced and precisely controlled.

2

Your impaired genes can only block a part of the unwanted fat absorption.

3

A portion of the excess fat is not absorbed and is thus excreted.

Gene diagram from page 29

Carbohydrates simply explained

If you follow diet trends, you have probably asked yourself the question: 'But what about carbohydrates? Don't they make you fat?' Of course, you are right. However, there are different types of carbohydrates.

Short-chain carbohydrates: rather unhealthyThe short-chain carbohydrates, which are considered rather unhealthy, are mainly found in sugar, but also in fruit. The body can process them quickly. However, this also results in the blood sugar level rising quickly and dropping faster. The result: One feels satiated for a shorter period of time and is tempted to eat more often, and this also makes it easier for cravings to occur.

Long-chain carbohydrates: healthy alternativeLong-chain carbohydrates, as found in potatoes or legumes, must first be broken down in the intestine. Therefore, they are absorbed more slowly by the body. For this reason, long-chain carbohydrates are considered the healthier alternative: They cause less disruption to blood sugar levels and keep you feeling full for longer.

The ADRB2-genes influence the effect of carbohydrates on body weight.

More carbohydrates

313 people

Normal weight | Weight gain

In a study, it was demonstrated that individuals (particularly women) with defective ADRB2-genes gained weight if they derived more than 50% of their calories from carbohydrates. However, if the ADRB2-genes were functional, the high carbohydrate intake did not result in being overweight.

Carbohydrates and their process in the body

If the genes are effective

In people with effective genes, excess carbohydrate calories are prevented from being stored as fat.

1

Carbohydrates are absorbed through food.

2

The effective genes prevent the storage of calories in the form of fat.

3

Excess carbohydrates are not stored as fat.

Gene diagram from page 32

If the genes are defective

In people with defective genes, excess carbohydrate calories are stored as fat.

1

Carbohydrates are absorbed through food.

2

The defective genes cannot prevent the storage of calories in the form of fat.

3

Excess carbohydrates are stored as fat.

Gene diagram from page 33

Daniel, here is your result

Sensitivity to carbohydrates is low
Due to your genes, you react slightly sensitively to carbohydrates. Therefore, foods high in carbohydrates are a minor factor in regards to weight gain for you.
Gene Genotype Function
ADRB2 (rs1042714) C/C

Your genes are effective

Since your genes are effective, they prevent excess carbohydrate calories from being stored as fat.

1

Carbohydrates are absorbed through your food.

2

Your functional genes prevent the storage of calories in the form of fat.

3

Carbohydrates are not stored as fat.

Gene diagram from page 35

Your summary

Fat

Moderate sensitivity to fat

Excessive intake of fat calories leads to moderate weight gain.

Carbohydrates

Low sensitivity to carbohydrates

Carbohydrate calories lead to minimal weight gain.

Protein

Moderate protein sensitivity

Protein calories in very large quantities lead to moderate weight gain.

Protein is an important nutrient that the body can use to build muscles and other tissues. However, protein also contains a lot of energy. Therefore, consuming too much protein can lead to weight gain. According to current scientific knowledge, genes do not influence the potential, excess weight gain caused by protein. Therefore, a standard amount of protein is planned in your diet.

Good to know

  • Depending on what type of diet you follow, there will be variations in the composition of carbohydrates, fats, and proteins. However, carbohydrates make up the majority of the diet for every type.

Daniel, you are a Carbohydrate Metabolizer

Your optimal distribution

This is how you should consume your daily calories:

20%

from fat

60%

from carbohydrates

20%

from protein

You are a Carbohydrate Metabolizer

What does that mean for you?

Pay attention to a fat-reduced diet. For you, carbohydrate calories are not contributing a lot to being overweight. On the other hand, fat calories are promoting excess weight gain. Therefore, a diet with more carbohydrates and less fats than usually recommended is most suitable for you. Your protein calories should be balanced.

Your recommended action

Reduce weight

1466 kcal/day

intake, consisting of:

12.0oz Fat

8.4oz Carbohydrates

1.9oz Protein

Maintain weight*

2224 kcal/day

intake, consisting of:

1.7oz Fat

12.7oz Carbohydrates

2.9oz Protein

* Maintaining weight refers to the phase in which you have already reached your desired weight.

Science of genes

Your genes in comparison

Here you will find out how your result, in terms of nutritional type, compares to the entire population.

The graphic shows the possible constellations of how often the respective genetic defects occur alone or in combination in the population.

Your result

C

C

FABP2 (rs1799883)

Both genes are functional

No effects on fat sensitivity

56%

of the general population is affected

 

C

T

FABP2 (rs1799883)

One gene defective

Increased fat sensitivity

38%

of the general population is affected

 

T

T

FABP2 (rs1799883)

Both genes are defective

Increased fat sensitivity

6%

of the general population is affected

 

T

T

FTO (rs9939609)

Both genes are functional

No effects on fat sensitivity

46%

of the general population is affected

Your result

T

A

FTO (rs9939609)

One gene defective

Increased fat sensitivity

41%

of the general population is affected

 

A

A

FTO (rs9939609)

Both genes are defective

Increased fat sensitivity

13%

of the general population is affected

 

G

G

PPARG (rs1801282)

Both genes are functional

No effects on fat sensitivity

1%

of the general population is affected

 

G

C

PPARG (rs1801282)

One gene defective

No effects on fat sensitivity

13%

of the general population is affected

Your result

C

C

PPARG (rs1801282)

Both genes are defective

Increased fat sensitivity

86%

of the general population is affected

Science (PubMed ID): 31675538 , 30026785 , 25502405 , 20580778 , 17898990 , 12630956 , 12145174

Your result

A

A

APOA2 (rs5082)

Both genes are functional

No effects on fat sensitivity

59%

of the general population is affected

 

A

G

APOA2 (rs5082)

One gene defective

No effects on fat sensitivity

34%

of the general population is affected

 

G

G

APOA2 (rs5082)

Both genes are defective

Increased fat sensitivity

7%

of the general population is affected

Science (PubMed ID): 26210798 , 26365669 , 24108135 , 21386805 , 20975728 , 19901143 , 17446329

 

G

G

APOA5 (rs662799)

Both genes are functional

No effects on fat sensitivity

3%

of the general population is affected

 

G

A

APOA5 (rs662799)

One gene defective

No effects on fat sensitivity

26%

of the general population is affected

Your result

A

A

APOA5 (rs662799)

Both genes are defective

Increased fat sensitivity

71%

of the general population is affected

Science (PubMed ID): 32335043 , 26365669 , 26524954 , 21209257 , 20696075 , 19828688 , 17211608

Your result

C

C

ADRB2 (rs1042714)

Both genes are functional

No impact on carbohydrate sensitivity

64%

of the general population is affected

 

C

G

ADRB2 (rs1042714)

One gene defective

Increased carbohydrate sensitivity

31%

of the general population is affected

 

G

G

ADRB2 (rs1042714)

Both genes are defective

Increased carbohydrate sensitivity

5%

of the general population is affected

Science (PubMed ID): 12888635

Exercise or Calorie Reduction?


Find out now whether, according to your genes, you can lose weight more effectively through exercise or by eating less.


Video thumbnail

How genes influence weight loss success through exercise or eating less

In the last chapter, you learned which type of weight loss type you are. So now you know whether fats or carbohydrates are more likely to cause weight gain for you. However, there are other ways to lose weight, which we will examine in more detail in this chapter.

Burning Calories through exerciseOne way to get rid of excess calories is to exercise. But before you head to the gym, you should know that your genes determine how much weight you can lose through exercise.

Save calories by eating lessThe second way is to simply consume fewer calories than you need. Your body then has no choice but to get the necessary energy from its fat reserves, helping you achieve a better figure. Genes also play an important role here as well. They define how effective calorie reduction actually is.

In this chapter, we find the strategy for effective weight loss that best suits your genes.

How genes influence the effectiveness of exercise

If the genes are effective

For people with effective genes, exercise is a good way to reduce their weight.

1

A person wants to lose weight through exercise.

2

The effective genes cause the person to lose weight with consistent training.

3

After four months of training, this person's weight loss is up to three times higher than people with different genes.

Gene diagram from page 44

If the genes are defective

For people with defective genes, exercise is less suitable for reducing their weight.

1

A person wants to lose weight through exercise.

2

The defective genes cause the person to not effectively lose weight, despite consistent training.

3

After four months of training, this person's weight loss is less than that of individuals with other genes.

Gene diagram from page 45

Daniel, here is your result

Losing weight through training is moderately effective
Due to your genes, exercise is only a slightly effective method to reduce your weight. While exercise is still important for your health, others lose body weight more easily through exercise.
Gene Genotype Function
ADRB3 (rs4994) A/A
FTO (rs9939609) T/A
PPARG (rs1801282) C/C

Your genes are impaired

Because your genes are affected, exercise is a moderately effective way for you to lose weight.

1

You want to reduce your body weight through exercise.

2

Your impaired genes cause you to only lose weight moderately despite consistent training.

3

After four months of training, your weight loss is somewhat less than that of individuals with effective genes.

Gene diagram from page 47

How genes influence calorie intake

If the genes are effective

For people with effective genes, eating less is a good way to reduce their weight.

1

A person wants to lose weight through calorie reduction.

2

The effective genes cause the person to lose weight through disciplined calorie reduction.

3

After four months of calorie reduction, this person's weight loss is higher than that of individuals with other genes.

Gene diagram from page 48

If the genes are defective

For people with defective genes, eating less is less suitable for reducing their weight.

1

A person wants to lose weight through calorie reduction.

2

The defective genes cause the person to not lose weight effectively despite disciplined calorie reduction.

3

After four months of calorie reduction, the weight loss of this person is less than that of people with other genes.

Gene diagram from page 49

Daniel, here is your result

Losing weight through calorie reduction is not effective
Due to your genes, eating less is not an effective method to reduce your weight. While a reduction in calories is still an important component of your weight loss program, individuals with other genes lose body weight more easily.
Gene Genotype Function
ADRB2 (rs1042714) C/C

Your genes are defective

Since your genes are defective, eating less is not an effective method for you to reduce your weight.

1

You want to lose weight through calorie reduction.

2

Your defective genes make weight loss more difficult despite disciplined calorie reduction.

3

After four months of calorie reduction, your weight loss is less than that of individuals with different genes.

Gene diagram from page 51

Your summary

Calorie reduction

Losing weight through calorie reduction is not effective

Saving calories by eating less only leads to minimal weight reduction.

Exercise

Losing weight through exercise is moderately effective

Burning calories through training leads to moderate weight loss.

Good to know

  • You can find your total calorie requirement from the 'Nutrition Type' result in the first chapter.

Daniel, you are an exercise type

Your weight loss strategy

Calorie reduction
Exercise

Exercise Type: Exercise is more effective for you to reduce your weight. On the other hand, a calorie reduction by eating less is not as successful. Therefore, the optimal strategy for you is to follow an intense exercise program and a light calorie reduction program.

Note

According to your genetic analysis, you are an exercise type. Nevertheless, we recommend that you save the majority of your calories by eating a balanced diet. This is easier to control and requires less time and commitment than exercise.

Your recommendation for action

Reduce weight

336

kcal/day

burnt through training

514

kcal/day

saved via food

Maintain weight*

112

kcal/day

burnt through training

* Maintaining weight refers to the phase in which you have already reached your desired weight.

Science of genes

Your genes in comparison

Here you will find out how your results, in terms of exercise or calorie reduction, compare to the total population.

The graphic shows the possible constellations of how frequently the respective genetic defects occur individually or in combination in the population.

Your result

A

A

ADRB3 (rs4994)

Both genes are functional

Increased weight reduction through exercise

78%

of the general population is affected

 

A

G

ADRB3 (rs4994)

One gene defective

Moderate weight reduction through exercise

20%

of the general population is affected

 

G

G

ADRB3 (rs4994)

Both genes are defective

Minor weight reduction through exercise

2%

of the general population is affected

Science (PubMed ID): 26888112 , 27330719 , 18054709 , 15166301 , 12917707 , 12406043 , 11743057 , 9661625 , 9405912

 

A

A

FTO (rs9939609)

Both genes are functional

Increased weight reduction through exercise

14%

of the general population is affected

Your result

A

T

FTO (rs9939609)

One gene defective

Moderate weight reduction through exercise

41%

of the general population is affected

 

T

T

FTO (rs9939609)

Both genes are defective

Minor weight reduction through exercise

45%

of the general population is affected

Science (PubMed ID): 25110886 , 23424664 , 21179003 , 20650268 , 19726594

 

G

G

PPARG (rs1801282)

Both genes are functional

Increased weight reduction through exercise

1%

of the general population is affected

 

G

C

PPARG (rs1801282)

One gene defective

Increased weight reduction through exercise

13%

of the general population is affected

Your result

C

C

PPARG (rs1801282)

Both genes are defective

Minor weight reduction through exercise

86%

of the general population is affected

Science (PubMed ID): 31675538 , 30026785 , 25502405 , 20580778 , 17898990 , 12630956 , 12145174

 

G

G

ADRB2 (rs1042714)

Both genes are functional

Increased weight loss through calorie reduction

5%

of the general population is affected

 

G

C

ADRB2 (rs1042714)

One gene defective

Increased weight loss through calorie reduction

31%

of the general population is affected

Your result

C

C

ADRB2 (rs1042714)

Both genes are defective

Slight weight reduction through calorie reduction

64%

of the general population is affected

Science (PubMed ID): 24960039 , 19186333 , 10093985 , 9399946

Preservation of Your Muscle Mass


Now, find out how your genes influence the maintenance of your muscle mass when losing weight and what this means for your choice of exercise.


Video thumbnail

How genes affect the maintenance of your muscle mass

A sad story from a prisonIn 1981, a hunger strike took place in a Northern Ireland prison regarding the conditions and their rights. Of the 23 inmates who began the strike, ten died as a result of malnutrition.

As sad as this story is, there was an interesting observation from a scientific perspective. The ten convicts died - after they had completely stopped eating - all after about 60 days, regardless of their initial weight or their possible fat reserves at the beginning of the hunger strike. Because the cause of death from starvation is not, as one might assume, the complete depletion of fat reserves, but the exhaustion of another energy source: the amino acids, which are found in our muscle mass among other things.

The danger of muscle loss

If a person completely stops eating, the body turns to the fat reserves to gain energy. However, some organs, such as the brain, require glucose as fuel. And this is obtained by breaking down amino acids. The body finds most of its amino acids in the muscles. Thus, the body is forced to start breaking down the muscles as an energy source, in addition to the fat reserves.

While the amount of fat reserves varies greatly from person to person, the available muscle mass is relatively similar among different people with few exceptions. Therefore, in the case of the ten convicts, it was similar yet eventually diminishing muscle mass that led to death at roughly the same time for all.

Unfavorable genes can accelerate muscle breakdown

Beneficial genes can help in muscle preservation

What we can learn from this: When losing weight, not only does the fat disappear, but muscle mass also decreases. However, genetic differences are crucial in determining how quickly weight is lost when reducing calories. Unfortunately, during a weight loss regimen with reduced calories, it is almost impossible to build muscle at the same time.

Therefore, we need to focus on maintaining your muscle mass as best as possible. Here again, your genes play a crucial role. Unfavorable genes can accelerate the loss of muscle mass during a weight loss regimen. Favorable genes, on the other hand, can assist in preserving the muscles while the fat is being reduced. Depending on the results, you should compensate for any possible genetic weaknesses with focused training.

How genes influence the preservation of muscle mass during weight loss

If the genes are effective

In people with effective genes, muscle mass is well maintained even when calorie intake is reduced.

1

Every person has a certain amount of muscle mass and fat tissue.

2

Effective genes help in maintaining muscle mass while fat tissue is being reduced during a calorie reduction.

Gene diagram from page 62

If the genes are defective

In people with defective genes, an undesired reduction of muscle mass occurs alongside fat tissue when calorie intake is decreased.

1

Every individual has a certain amount of muscle mass and adipose tissue.

2

Defective genes do not help in maintaining muscle mass during a calorie reduction. In addition to fat tissue, muscle mass is also reduced.

Gene diagram from page 63

Daniel, here is your result

Muscle mass loss low
Due to your genes, you tend to lose less muscle mass than people with other genes when you reduce calories. For this reason, endurance training is sufficient for you to best support your muscle mass.
Gene Genotype Function
ADRB2(rs1042714) C/C

Your genes are effective

Since your genes are effective, muscle mass is well preserved even with a reduction in calories.

1

Due to your effective genes, tend to not lose as much muscle mass when reducing calories.

2

Endurance sports are sufficient to maintain the muscles.

3

Muscle mass is preserved, while fat tissue is broken down.

Gene diagram from page 65

Your summary

Muscle mass loss

Muscle mass loss is minimal with calorie reduction

Due to your genes, you tend to lose less muscle mass than other people when reducing calories. For this reason, endurance training is sufficient for you to best support your muscle mass.

Good to know

  • Muscles play a significant role in weight regulation. They burn more calories at rest than fat tissues, even without exercise. Therefore, maintaining a certain amount of muscle mass helps in losing or maintaining weight.

Daniel, you are an endurance exercise type

Your optimal distribution

Perform

30%

Strength training

70%

Endurance training

You are an endurance exercise type

What does that mean for you?

If you want to lose weight through calorie reduction, your muscle mass is relatively well preserved. So, you can burn calories predominantly with endurance training, without your muscle mass suffering.

What does this mean for your training plan?

Try to engage in endurance training for most of your exercise.

Endurance training is understood as moderate exertion over an extended period of time. Weightlifting, on the other hand, involves exercises that push the limit of maximum strength in the short term.

More details

In the last part of your report, you will find exercise programs that match your genes and other recommendations on how you can integrate your results into your everyday life.

Science of genes

Your genes in comparison

On this page, you will learn how your result, in terms of maintaining your muscle mass, compares to the entire population.

The graph shows the possible arrangements and how often the respective genetic defects occur individually or in combination in the population.

Your result

C

C

ADRB2 (rs1042714)

Both genes are functional

Less muscle mass loss during calorie reduction

64%

of the general population is affected

 

C

G

ADRB2 (rs1042714)

One gene defective

Moderate muscle mass loss during calorie reduction

31%

of the general population is affected

 

G

G

ADRB2 (rs1042714)

Both genes are defective

High muscle mass loss with calorie reduction

5%

of the general population is affected

Science (PubMed ID): 20523301

Control Over Feelings of Hunger and Satiety


Learn how your genes control your hunger and satiety feelings and how you can deal with it.


Video thumbnail

How your genes control your hunger and satiety feelings

In this chapter, we will explore how genes precisely regulate human food intake and ensure that neither too much nor too little is eaten.

However, these genes are not infallible. Sometimes they tempt one to exceed their daily calorie target or to reach for particularly calorie-rich foods.

You may have also wondered why you are hungry again? You will find that answer in this chapter as well. This is because, feeling the desire to snack between meals or how long satiety lasts, all depends on your genes.

Therefore, it is important for you to be informed about such possible genetic weaknesses. This way, you can counteract with the right measures.

How genes influence our calorie intake

Genes not only control mechanical processes in the body, but also our psyche.

Hunger and genesHunger is an important process that drives us and our animal cousins to seek out food. While in the Stone Age we armed ourselves with bows and arrows to go hunting, today, a short trip to the refrigerator suffices. We have specific genes to remind us that we are not immediately hungry again after a meal, but we are increasingly reminded after a longer fasting period that we should go in search of food again. Our genes help to precisely regulate the intensity of hunger. However, these genes are not flawless. That's why some of us are plagued by hunger more than others.

Satiety and genesWhen hunger finally wins and a meal ends up in the intestines, the satiety process begins. Certain nutrients that are absorbed in the small intestine activate the production of a satiety hormone that makes hunger disappear. It signals to the body that it has now eaten enough. However, genetic differences also exist here, which delay the onset of satiety. The frequent consequence is overeating, and the resulting gains in weight.

What tastes best to usIn an interesting experiment, scientists placed hungry people with an empty plate in front of a buffet. The task was to put what they wanted to eat on the plate. Afterwards, the calorie count on each plate was measured and a gene analysis was carried out on all people. The result: Those people with the defective version of the responsible gene had significantly more calories on the plate than the study participants with the normal version of the gene. This gene defect apparently tempts people to prefer particularly calorie-rich foods.

A snack in between?In other studies, it has been observed that people with certain genetic defects tend to snack a lot more. Thus, they tend to intake additional calories between their main meals. When these extra calories get out of control, body weight increases.

How genes influence the feeling of hunger

If the genes are effective

In people with effective genes, the feeling of hunger is normal.

1

The genes regulate the feeling of hunger.

2

The feeling of hunger occurs relatively late and at a normal intensity.

Gene diagram from page 74

If the genes are defective

In people with defective genes, the feeling of hunger is significantly stronger.

1

The genes do not regulate the feeling of hunger well.

2

The feeling of hunger develops faster and is particularly strong.

Gene diagram from page 75

Daniel, here is your result

Strong hunger type
Your genes afflict you with a stronger sense of hunger than is the case for people with more favorable genes. It is better to spread your meals over six small ones rather than three large ones per day. This allows you to avoid longer periods without eating. The last section of the report lists snacks that are always allowed in between your main meals.
Gene Genotype Function
FTO (rs9939609) T/A

Your genes are defective

Since your genes are defective, you have a stronger feeling of hunger.

1

Your genes regulate the feeling of hunger.

2

Due to your genes, you develop a feeling of hunger earlier. Low-calorie snacks help delay the feeling of hunger.

3

Through smaller meals and low-calorie snacks, your feeling of hunger is not so strong.

Gene diagram from page 77

How genes affect your choice of calories

If the genes are effective

People with effective genes tend to consume less calorie-rich foods during their meals.

1

The genes control the desire for food.

2

The effective genes make the person reach for less calorie-rich foods.

Gene diagram from page 78

If the genes are defective

People with defective genes tend to choose more calorie-rich foods for their meals.

1

The genes control the desire for food.

2

The defective genes tempt the person to reach for higher calorie foods.

Gene diagram from page 79

Daniel, here is your result

Moderate calorie intake type
Due to your genes, you're a bit more prone to reach for particularly high-calorie foods. Be aware that your genes sometimes try to tempt you. Therefore, stick to the green-rated foods in your individual food list, located within your portal, to counteract your genes.
Gene Genotype Function
FTO (rs9939609) T/A
APOA2 (rs5082) A/A

Your genes are impaired

Since your genes are impaired, you tend to reach for high-calorie foods during your meals.

1

Your genes control your desire for food.

2

Stick to the green rated foods to counteract your impaired genes, which are more likely to tempt you towards calorie-rich foods.

Gene diagram from page 81

This is how genes influence the feeling of satiety

If the genes are effective

People with effective genes have a strong feeling of satiety.

1

Genes influence the feeling of satiety when eating a meal.

2

The effective genes ensure that the body's signal that it is full is immediately recognized. The feeling of satiety is strong.

Gene diagram from page 82

If the genes are defective

People with defective genes have a weak sense of satiety.

1

Genes influence the feeling of satiety when eating a meal.

2

The defective genes slow down the body's signal that it is actually full. The feeling of satiety is weak and the person tends to overeat uncontrollably.

Gene diagram from page 83

Daniel, here is your result

Weak satiety type
Due to your genes, the signal from your body that it is actually satisfied slows down. This often leads to uncontrollable overeating. You will find it difficult to maintain longer breaks between meals. Take your time during your meals to give your body a chance to develop a feeling of satiety.
Gene Genotype Function
FTO (rs9939609) T/A

Your genes are defective

Since your genes are defective, you have a weak feeling of satiety.

1

Your genes influence your feeling of satiety when eating a meal.

2

Your defective genes slow down the onset of your feeling of satiety. Take enough time during meals so that the feeling of satiety can develop.

Gene diagram from page 85

How genes influence snacking behavior

If the genes are effective

People with effective genes tend to snack less than individuals with defective genes.

1

Genes influence the desire for snacks between meals.

2

Due to the effective genes, these individuals have less desire to snack between meals.

Gene diagram from page 86

If the genes are defective

People with defective genes tend to snack more than individuals with effective genes.

1

Genes influence the desire for snacks between meals.

2

Due to the defective genes, these individuals have a greater desire to snack more often between meals.

Gene diagram from page 87

Daniel, here is your result

Strong snacking tendency
Due to your genes, you tend to snack more often than people with effective genes. Be aware of this temptation and make sure you opt for low-calorie options when you feel the need. You can find a list of recommended snacks in the last part of your report.
Gene Genotype Function
FTO (rs9939609) T/A

Your genes are defective

Since your genes are defective, you tend to snack more than people with effective genes.

1

Your genes influence your desire for snacks between meals.

2

Due to your defective genes, you have a greater desire to snack between meals. Be aware of this and choose low-calorie alternatives when you snack.

Gene diagram from page 89

Science of genes

Your genes in comparison

On this page, you will find out how your results, regarding hunger and satiety, compare to the entire population.

The graphic shows the possible constellations and how often the respective genetic defects occur alone or in combination within the population.

 

T

T

FTO (rs9939609)

Both genes are functional

No effects

46%

of the general population is affected

Your result

T

A

FTO (rs9939609)

One gene defective

Increased hunger sensation Tendency to eat more calorie-rich food Weak feeling of satiety Tendency to eat more snacks

41%

of the general population is affected

 

A

A

FTO (rs9939609)

Both genes are defective

Increased hunger sensation Tendency to eat more calorie-rich food Weak feeling of satiety Tendency to eat more snacks

13%

of the general population is affected

Science (PubMed ID): 19828706 , 19726594 , 18583465 , 31119882

Your result

A

A

APOA2 (rs5082)

Both genes are functional

No effects

59%

of the general population is affected

 

A

G

APOA2 (rs5082)

One gene defective

No effects

34%

of the general population is affected

 

G

G

APOA2 (rs5082)

Both genes are defective

Tendency to eat more calorie-rich food

7%

of the general population is affected

Science (PubMed ID): 19901143 , 17446329

Fat Distribution - Where Fat Accumulates


How do genes influence your fat distribution? And what does this mean for your health?


Video thumbnail

How your genes control where you accumulate fat

Obesity is not the same as being overweight. Fat deposits in the body can form at different places. While fat around the hips may be aesthetically undesirable, it has significantly fewer negative impacts on health than the so-called visceral fat, which accumulates around the organs in the abdomen.

Visceral fat is very unhealthy because it is metabolically active, it contains messenger substances that influence various processes in the body. For example, inflammation and metabolic processes. An excess of visceral fat can increase the risk of cardiovascular diseases like heart attacks or strokes as well as metabolic diseases like type 2 diabetes mellitus. The 'normal' subcutaneous fat, on the other hand, is not metabolically active.

In this chapter, you will learn about the influence genes have on fat distribution and why, as a result, it is even more crucial for some people to maintain an optimal body weight than others.

How genes influence fat distribution

If the genes are effective

People with effective genes tend to store excess fat outside of the organs, around the hips.

1

An excess of calories is eaten.

2

The body absorbs the calories and begins to store them in the body as adipose tissue.

3

The fat primarily forms around the hips, outside of the abdominal cavity.

Gene diagram from page 94

If the genes are defective

People with defective genes store excess fat more around the organs.

1

An excess of calories is being eaten.

2

The body absorbs the calories and begins to store them in the body as fat tissue.

3

The fat accumulates predominantly around the organs, in the abdominal cavity.

Gene diagram from page 95

Daniel, here is your result

Weak fat organ type
Your genes protect you from excessive accumulation of fat around the organs in the abdominal cavity. Fat around the organs is metabolically active. This means that it is worse for the health than fat around the hips. Therefore, your genes provide you with optimal protection in this regard.
Gene Genotype Function
FABP2 (rs1799883) C/C
PPARG (rs1801282) C/C
ADRB2 (rs1042714) C/C
APOA2 (rs5082) A/A

Your genes are effective

Since your genes are effective, they protect you from excessive fat deposition around the organs in the abdominal cavity.

1

Make sure you don't consume too many calories.

2

Your body absorbs the available calories and consumes the majority of them without storing the calories as adipose tissue.

3

If there is an excess of calories, the fat would be stored around the hips. This can be prevented by reducing the calorie intake.

Gene diagram from page 97

Science of genes

Your genes in comparison

On this page, you will find out how your fat distribution result compares to the entire population.

The graphic shows the possible constellations of how frequently the respective genetic defects occur alone or in combination in the population.

Your result

C

C

FABP2 (rs1799883)

Both genes are functional

No effects

56%

of the general population is affected

 

C

T

FABP2 (rs1799883)

One gene defective

Increased risk of fat deposits around the organs

38%

of the general population is affected

 

T

T

FABP2 (rs1799883)

Both genes are defective

Increased risk of fat deposits around the organs

6%

of the general population is affected

Your result

C

C

PPARG (rs1801282)

Both genes are functional

No effects

86%

of the general population is affected

 

C

G

PPARG (rs1801282)

One gene defective

Increased risk of fat deposits around the organs

13%

of the general population is affected

 

G

G

PPARG (rs1801282)

Both genes are defective

Increased risk of fat deposits around the organs

1%

of the general population is affected

Science (PubMed ID): 31675538 , 17898990

Your result

C

C

ADRB2 (rs1042714)

Both genes are functional

No effects

64%

of the general population is affected

 

C

G

ADRB2 (rs1042714)

One gene defective

Increased risk of fat deposits around the organs

31%

of the general population is affected

 

G

G

ADRB2 (rs1042714)

Both genes are defective

Increased risk of fat deposits around the organs

5%

of the general population is affected

Science (PubMed ID): 23911093 , 19832974 , 15672110

Your result

A

A

APOA2 (rs5082)

Both genes are functional

No effects

59%

of the general population is affected

 

A

G

APOA2 (rs5082)

One gene defective

Increased risk of fat deposits around the organs

34%

of the general population is affected

 

G

G

APOA2 (rs5082)

Both genes are defective

Increased risk of fat deposits around the organs

7%

of the general population is affected

Science (PubMed ID): 26365669 , 21386805

You Have Reached Your Desired Weight. What Happens Now?


Whether you quickly regain weight after weight reduction depends on your genes.


Video thumbnail

How your genes influence whether you regain weight quickly

Genes remain the same throughout life and do not change. Thus, the genetic characteristics and tendencies in this report will accompany you throughout your life, without having to take a genetic test again.

That's why it's so important for you to decide to permanently change your lifestyle and find a path that you can easily implement. Without a lasting strategy, certain gene defects can quickly undo your successful efforts.

In this chapter, you will find out whether your genes support you in maintaining your weight or whether you gain weight more quickly.

The Yo-Yo Effect


Since your genetic tendencies remain the same throughout your life, it will now be easy to permanently optimize your lifestyle. Have we promised too much?


Maintaining weight through a permanent lifestyle change.

Many know this: After a lot of effort to lose weight and get through the summer beach season well, suddenly you slip back into old habits. The weight starts to increase again. This is the infamous yo-yo effect.

Here too, genes play a role. Studies have shown that people with certain gene defects regain weight much faster and easier than people with other genes. So, your own genes can help you maintain the weight you've worked hard for - or they may work against your own wishes.

How genes influence weight stability

If the genes are effective

People with effective genes are protected against rapid weight regain.

1

A successful diet leads to the desired weight loss.

2

Through old habits and diet, weight increases very slowly again due to protective genes.

Gene diagram from page 106

If the genes are defective

People with defective genes tend to regain weight faster.

1

A successful diet leads to the desired weight loss.

2

Due to old habits and diet, weight increases very quickly again due to defective genes.

Gene diagram from page 107

Daniel, here is your result

Weaker yo-yo type
Your genes protect you from rapid weight regain after successful weight loss. Your genes easily help you maintain your weight. Still, after successful weight loss, make sure you follow the basic rules of this report to support your body.
Gene Genotype Function
PPARG (rs1801282) C/C
ADRB2 (rs1042713) A/A
ADRB2 (rs1042714) C/C

Your genes are effective

Since your genes are effective, they support you in maintaining your weight.

1

You have successfully lost weight.

2

Through old habits and diet, the weight would only increase very slowly. Nevertheless, the new lifestyle additionally helps you to maintain your weight in the long term.

Gene diagram from page 109

Science of genes

Your genes in comparison

On this page, you will find out how your results, in terms of the yo-yo effect, compare to the overall population.

The graphic shows the possible constellations of how frequently the respective genetic defects occur alone or in combination in the population.

Your result

C

C

PPARG (rs1801282)

Both genes are functional

No effects

86%

of the general population is affected

 

C

G

PPARG (rs1801282)

One gene defective

Strong Yo-Yo effect

13%

of the general population is affected

 

G

G

PPARG (rs1801282)

Both genes are defective

Strong Yo-Yo effect

1%

of the general population is affected

Your result

A

A

ADRB2 (rs1042713)

Both genes are functional

No effects

23%

of the general population is affected

 

A

G

ADRB2 (rs1042713)

One gene defective

Strong Yo-Yo effect

49%

of the general population is affected

 

G

G

ADRB2 (rs1042713)

Both genes are defective

Strong Yo-Yo effect

28%

of the general population is affected

Science (PubMed ID): 17378367 , 16280290 , 15956122

Your result

C

C

ADRB2 (rs1042714)

Both genes are functional

No effects

64%

of the general population is affected

 

C

G

ADRB2 (rs1042714)

One gene defective

Strong Yo-Yo effect

31%

of the general population is affected

 

G

G

ADRB2 (rs1042714)

Both genes are defective

Strong Yo-Yo effect

5%

of the general population is affected

Science (PubMed ID): 24960039 , 16280290 , 10093985 , 9399946

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Made in Austria

Dr. Daniel Wallerstorfer

Dr. Daniel Wallerstorfer

Chief Scientific Officer, 10X Health

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Technical details of your analysis

Order number

PBA1331

Date of birth

02/11/1982

Analysis method

DNA Microrray

Surname, First name

Wallerstoffer, Daniel

Report created

09/08/2024

Current version

V.1.1

Laboratory

Novogenia GmbH
Strass
5301 Eugendorf
AUSTRIA

Responsible Company

10X Health 2920 NE 207th St #901 Miami, FL 33180 USA

Laboratory Director

Signature

Dr. Daniel Wallerstorfer Bsc.

Laboratory Manager

Signature

René Rohrmanstorfer, M.Sc.

Imprint

Novogenia GmbH, Strass 19, 5301 Eugendorf, AUSTRIA

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